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2-Bromo-3'-chloropropiophenone (BCP) 2-Bromo-3'-chloropropiophenone (BCP) 2-Bromo-3'-chloropropiophenone (BCP) 2-Bromo-3'-chloropropiophenone (BCP)

2-Bromo-3'-chloropropiophenone (BCP)

1800.0 INR/Kilograms

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2-Bromo-3'-chloropropiophenone (BCP) Price And Quantity

  • 1800.0 INR/Kilograms
  • 100 Kilograms

2-Bromo-3'-chloropropiophenone (BCP) Trade Information

  • Nhava Sheva, Mumbai, India
  • Telegraphic Transfer (T/T)
  • 100000 Kilograms Per Month
  • 2 Week
  • Yes
  • Sample costs shipping and taxes has to be paid by the buyer
  • HDPE Drum
  • Asia Australia Central America North America South America Eastern Europe Western Europe Middle East Africa
  • ISO 9001:2015: Quality Management System ISO 45001:2018: Environmental Management System ISO 14001:2015: Occupational Health & Safety Management System & GMP Certified

Product Description

2-Bromo-3'-chloropropiophenone (BCP) is a yellow oil with the chemical formula C9H8BrClO. It is an intermediate used in the synthesis of bupropion, a common antidepressant, and is also found as an impurity in bupropion hydrochloride. BCP has a CAS number of 34911-51-8 and a molecular weight of 247.52 g/mol. It is soluble in dichloromethane and has a boiling point of 295C at 760 mm Hg. 

Chemical Name:2-Bromo-3'-chloropropiophenoneSynonyms2-BROMO-1-(3-CHLOROPHENYL)PROPAN-1-ONE;DK749;2B3CP;2-Bromo Bupropion;Bupropion Impurity 5;Bupropion Impurity 42;Bupropion impurity M1-9;Bromo Chloropropiophenone;Bupropion 2-BroMo IMpurity;Bupropion Related Compound GCBNumber:CB3271779Molecular Formula:C9H8BrClOMolecular Weight:247.52

Health Hazard

2-Bromo-3'-chloropropiophenone is irritating to the eyes, respiratory system, and skin.

Uses

2-Bromo-3'-chloropropiophenone is used as an important intermediate for raw material and intermediate used in organic synthesis agrochemical, pharmaceutical and dyestuff field.

Definition

2-Bromo-3'-chloropropiophenone (BCP), a yellow oil, is an intermediate used in the synthesis of bupropion and is also found as an impurity of bupropion hydrochloride. Bupropion is a second-generation antidepressant that was originally approved by the United States Food and Drug Administration (FDA) in 1985. It is a norepinephrine and dopamine transporter inhibitor and an antagonist at neuronal nicotinic acetylcholine receptors. Bupropion is also approved for smoking cessation[1].

Safety

The current United States Pharmacopeia (USP) specification is for no more than 0.1% BCP in the bupropion hydrochloride monograph. The Material Safety Data Sheet from a manufacturer indicates that BCP is irritating to the eyes, respiratory system, and skin. 2-Bromo-3'-chloropropiophenone was mutagenic with S9 metabolic activation, increasing the mutant frequencies in a concentration-dependent manner, up to 22- and 145-fold induction over the controls in Salmonella strains TA100 and TA1535, respectively. BCP was also positive in the in vitro micronucleus assay, resulting in up to 3.3- and 5.1-fold increase of micronucleus frequency for treatments in the absence and presence of S9, respectively; and 9.9- and 7.4-fold increase of aneuploidies without and with S9, respectively. The addition of N-acetyl-l-cysteine, an antioxidant, reduced the genotoxicity of BCP in both assays. Further studies showed that BCP treatment resulted in induction of reactive oxygen species (ROS) in the TK6 cells. The results suggest that BCP is mutagenic, clastogenic, and aneugenic, and that these activities are mediated via generation of reactive metabolites[1].

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